|
KMID : 0363320080290030800
|
|
Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.800 ~ p.809
|
|
|
The Clinical Effect of Bosingunyang-tang on Chronic Non-bacterial Prostatitis/Chronic Pelvic Pain Syndrome : Randomized Double-blind, Placebo-controlled Clinical Trial
|
|
Song Moon-Koo
Kang Ji-Suck
Kang Cheol-Ho
Ahn Young-Min
Ahn Se-Young
Doo Ho-Kyung
Lee Byung-Cheol
|
|
|
Abstract
|
|
|
Objective : Although chronic prostatitis/chronic pelvic pain syndrcme(CP/CPPS) is a common disease, there is no consensus on the etiology or pathology and treatment. This was a double-blinded, placebo-controlled, randomized clinical trial, investigating the therapeutic effects of the traditional Korean medicine, Bosingunyang-tang(BSGYT).
Method : Participants who met US National Institutes of Health (NIH) consensus criteria for CP/CPPS were entered after applying inclusion/exclusion criteria. They were randomized to the BSGYT or placebo group. and treated three times a day for 6 weeks. NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was used to estimate the clinical symptoms of CP/CPPS. Prostaglandin E2 and -endorphin in prostatic fluid, collected by 2-glass pre-massage and post-massage test, were analyzed as factors associated with pain and inflammation.
Result : The mean decrease in NIH-CPSI total score of the BSGYT group was 11.0 points, which is 5.7 points more than the placebo group. (Mann Whitney test P=0.038) Also the BSGYT group showed three times higher response rate than the placebo group in NIH-CPSI pain subscale score. (Fisher’s exact test P=0.027) In those responders, prostaglandin E2 decreased significantly. (Wilcoxon’s signed-ranks test P=0.037). No specific side effects were observed.
Conclusion : After a 6-week treatment period, BSGYT improved clinical symptoms of CP/CPPS patients by decreasing PGE2 level in prostatic fluid.
|
|
|
KEYWORD
|
|
|
Bosingunyang-tang, chronic prostatitis, chronic pelvic pain syndrome, prostaglandin E2, Bushenjianyang-tang
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|